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by timr 893 days ago
The argument wasn't specific to Covid. The people who get "severe viral infections" tend to be people who are old and unhealthy to begin with. When you start with a population of medical records (as this study did) you unavoidably bias your sample toward sicker people.

Observational studies don't/can't perfectly correct for this residual confounding. This exact error has been repeatedly made by "long Covid" research as well (most notably by Ziyad Al-Aly, who has published a half dozen different articles on Long Covid using the same confounded, observational VA medical record dataset, and claimed associations with a huge number of different illnesses. This research is garbage, but it has scared people out of their wits.)