[jeroenhd]

I use BTRFS with compression because my SD card is old (like, a decade old) and slow. (De)ompressing the assets takes a bit of CPU time but the slow I/O is noticeably faster because of it.

Deduplication can be useful if you store the Proton/Wine runtimes on the same disk. Different games may need different runtimes, the latest version isn't always the best, and a Wine environment without any games inside of it can take up a couple hundred megabytes just for DLLs and other common dependencies. Deduplicating can save a chunk of wasted storage, although with current flash storage prices that's probably not worth worrying about in practice.

Some people like the checksumming but IMO that's not all that useful without ECC memory.