[skepticATX]

I have to agree.

I don’t think that being obese is a moral failing at all. But caloric deficit does result in weight loss.

Anyways, there are plenty of other benefits that come from exercise and a healthy diet, besides weight loss. Hopefully these drugs can be used as part of a more holistic improvement in lifestyle, and not as a sole treatment.

[orwin]

I was clinically obese (32 BMI when I checked, I think it could have been higher). The hunger when on calorie restrictions was debilitating, making it impossible to work in the afternoons.

The thing that helped was a complete, week-long fast (I had 13 weeks of PTO per year so sacrifing 2 wasn't a huge deal then), that I prepared with my family (lot of them are either doctors or PT). The second day was worse than when I dislocated my ankle, except in my whole body, without the adrenalin/shock to help with the pain. The pain came in waves. Once that passed I was mostly fine, and the third day until the last I was mostly functioning (I tired easily, and couldn't work or really exercise, but I was mostly fine and could go out and walk).

If I knew those drug existed, I think I couldn't have passed that second day, and taken those instead.