[RiDiracTid]

Empirically, many bacteria seem to be able to acquire resistance in a way that doesn't significantly impact their fitness, meaning they can basically get new resistances and keep old ones for almost arbitrarily long, so the crop rotation idea would fail massively.

https://academic.oup.com/femsre/article/35/5/901/2680377

[Log_out_]

It has costs. Replication gets more expensive and slower, more error prone. Also bacteria exchanges resistance DNA among itself. Would be a cool vector to give them weekness.

[schneems]

Good to know, thanks for the explanation!