[bjnewman85]

paper link here https://www.nature.com/articles/s41557-023-01383-y i thought this sentence from the abstract was interesting 'Given that a cell is unlikely to develop resistance to such molecular mechanical forces...' I wonder if someone could explain what basis there for believing that cells couldn't develop such resistance. Is the difference in energies that high?

[chrisbrandow]

I think that the reasoning is that no cells will have even partial resistance to mechanical action, therefore "fitness" wouldn't develop in surviving cells. i.e. there's no fitness function with improve upon. Perhaps the ability of these dye molecules to infiltrate could be affected, but given the fundamental structure of cells, that may not be a likely outcome within a single human organism (since cancer is generally non-communicative)