[jseliger]

But that's the problem, you only know what's safe in hindsight

That's part of the point: safetyism is a problem: https://en.wikipedia.org/wiki/Safetyism. If you personally want to wait until more data is in, then wait, but let the rest of take reasonable risks to move things along. I would, and want to, and suspect many others will too.

Every time a standard-of-care treatment is safe and effective you can thank the FDA for doing the unglamorous work of holding these companies accountable

Every time someone dies because the FDA has killed or slowed effective treatments, you can thank them for doing the unglamorous work of holding back progress. The dead aren't posting to Hacker News.

Give me (and others) the freedom to try. I'm a dead man walking anyway, which you don't seem to get, or acknowledge.