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by vik0 925 days ago
What actual value did 23andMe and similar services offer in the first place?

Quenching someone's curiosity about where their ancestors are from? Do we even know how accurate it is at doing that?

5 comments

If you go back in time, 23andMe was founded to collect genetic data with the goal of using that data to improve the health condition of humanity.

Over time it became clear that 23andMe's data set had limited predictive ability for health for a number of technical reasons (previously, dahinds, one of their statistical geneticists, has defended the quality of their predictions on HN, you can search for his comments. I suspect he can no longer comment on HN because of 23&Me's security debacle).

However, around that same time, 23&Me's dataset turned out to be excellent for ancestry analysis. It's generally considered fairly accurate (not just 23&Me- the entire process of ancestry through snp genotyping workings really well).

I never did 23&Me but my dad did- and he learned he has children all around the US (half brothers and sisters of mine) from some samples he provided some 45+ years ago. Both my dad and those people gained value from making that connection. It's interesting because my dad had already done most of the paper research (including going to SLC to visit the Mormon archives) to identify our obvious ancestors, and these relatives would never have shown up.

Ancestry data, but also health markers. I.e. you're probably going to get macular degeneration, Tay-Sachs and cervical cancer.

Once I enabled the social graph thing I was immediately hounded by distant relatives who I assume want to chop me up for parts.

> Do we even know how accurate it is at doing that?

The police have closed a few cold murder cases based on adjacency (once Parabon got their hands on samples), so it must be pretty accurate.

Anecdotally, my profile told a radically different story about our ancestry than my family's vague lore led me to believe. 23andMe's data made way more sense.

I was adopted. I have no idea who my biological parents were or what genetic risks I might have inherited from them. When the doctor asks "Has anyone in your family ever had <fill in the blank>?" I have no answer to those questions without a genomic test.
I just wanted to confirm my connection to royalty because I've always felt, y'know... special
Locating secret/hidden family is kinda nice.