[mettamage]

Disclaimer: not a physicist.

It seems to me that one issue with falsification is that: if you're exactly right on how the universe works, then it's hard to know that you are exactly right. So I imagine that we'd be infinitely putting resources in it (to some extent) to see if anything is unexplained. So if the universe is just like that, then we'd have a long way to go to find out.

I do think that physicists are bothered by the idea that current theories can't explain everything they're observing. So whether the universe is or isn't like that, more research is definitely needed.