[collegeburner]

this is my napkin math read as well, but aspirin is an inhibitor of both COX-1 and 2 with somewhat higher affinity for the former. this leaves you messing with something else that's important for regulating platelets, your gut, etc. even selective inhibitors of the latter aren't out of the woods yet. there's some literature that's starting to suggest COX-2 may be at least somewhat constitutive in some tissues (endothelium, hence coronary vasospasm) even if it's also mostly inducible.

not sure why no one has tried developing a prostaglandin e2 inhibitor instead. going further downstream might be safer.