[manmal]

There might be a timing aspect to it - eg by boosting mTOR only in the morning (protein rich breakfast etc).

[Attummm]

Circadian rhythm of the body timing is quite important.

There is some research pointing towards that most hunger pangs not caused by daily eating schedule are protein related.

[manmal]

I think it’s multifactorial, but yes, protein is definitely an important part. Impaired gluconeogenesis or glycogen production, or insulin resistance could be other factors there. Chromium, vanadium, zinc, copper, selenium, iron, iodine deficiencies can all lead to problems in those areas. Certain (micro)biome pathogens, too, eg acetaldehyde producers.