[swader999]

Yup, I think all the meds for this can succumb to tolerance. A real life Flowers for Algernon. Over the years I've upped the dose, switched meds, drug holidays but nothing has matched how well my brain worked the first couple of years on meds.

[muhblah]

> nothing has matched how well my brain worked the first couple of years on meds

As someone who also has a bit more than 2 decades experience with ADHD medication and started with meds quite early in my teenage years when I went to school, I have very similar experience to yours.

One of my assumptions is that it also has a lot to do with the humans metabolism that changes over the years.

[JohnBooty]

    One of my assumptions is that it also has a lot 
    to do with the humans metabolism that changes 
    over the years. 

That theory makes sense to me. However, my anecdotal experience is that I never tried any of these meds until my early 30's.

The first few weeks on Adderall were f'ing magical. I remember tearing up, I was so happy. Finally I was laser-focused. A bit emotional thinking of it now.

The magic faded fast. Adderall was still a large net positive for me for ~6-7 years. But never like those first few weeks. I guess I got somewhat close to that original experience a few times, after extended breaks from Adderall and restarting it.

Anyway, this is of course a sample size of 1. But since all the experiences described above took place in my 30s I don't think that metabolism change was a major factor. Certainly not within the first year. Again I know... n=1 =)

[JohnBooty]

Well, I'm jealous. For me it was literally like... the first few weeks on adderall lol.

I continued to benefit from it for ~6-7 years. But, never felt anything like those first few weeks.