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by Obscurity4340 959 days ago
What is the gold standard currently? Like phentermine or diethylpropion? Or is it actually Ozempic?
1 comments
aantix 959 days ago
Of FDA approved medications for weight loss, tirzepatide would be the current gold standard.

https://www.nejm.org/doi/full/10.1056/nejmoa2107519

I think retatrutide might be the current leader for weight loss from clinical trials.

If I remember correctly, you lost the same amount of weight on retatrutide vs tirzepatide, but over a shorter time span.

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Obscurity4340 959 days ago
You're saying this NEW medication is already currently the gold standard? What was it prior?
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quux 959 days ago
The active ingredient, tirzepatide, isn't what's new here. It was patented in 2016 and has been on the market for treating type 2 diabetes since 2021.

What's new is that tirzepatide is now FDA approved for treatment of obesity, which will make it possible for insurance to cover it without a type 2 diabetes diagnosis.

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bb88 959 days ago
It should also be noted that during those original studies significant weight loss was observed, which is why doctor's were prescribing tirzepatide off-label.

Also just like Ozempic/Wegovy, Mounjaro is still indicated for type 2 diabetes. Zepbound will be the weight loss drug.

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Obscurity4340 959 days ago
Can people still get insurance to cover stuff like Ozempic (generic or otherwise) even if its technically prescribed off-label?
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bb88 959 days ago
Depends upon the insurance.

The doctor can certainly prescribe it though.

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