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by jfengel 957 days ago
I see that it's another GLP-1 agonist, like Ozempic/Wegovy. Are there any particular advantages, or is it just a me-too drug?
4 comments

It's a GIP agonist as well.

The weight loss number surpass that of semaglutide alone. https://www.nejm.org/doi/full/10.1056/nejmoa2107519

It is a double agonist, the second being GIP. Retatrutide, still in trials, is an even more efficacious triple agonist,
"Semaglutide simulates a single hormone in the body, while tirzepatide [active ingredient in Zepbound] mimics two, which experts say may be why it’s often more effective at triggering weight loss."

From: https://www.nytimes.com/2023/11/08/well/zepbound-mounjaro-we...

This is also known as Mounjaro when prescribed for diabetes. Its also a GIP agonist in addition to GLP-1.