[derefr]

> The real sci-fi moment will be when they get to the point they can treat in a day.

How do you imagine that would work?

Some closed-pipeline machine that lives in the hospital and automates sample → modified sample culture cycle?

Or something stranger, e.g. some kind of injectable (maybe prokaryotic?) cells that actively swim around looking for L-lymphocytes to vectorize through bacterial horizontal gene transfer — such that the whole process happens in vivo?

[puzzlingcaptcha]

> Some closed-pipeline machine that lives in the hospital and automates sample → modified sample culture cycle?

That's already a thing, for example Lonza's Cocoon platform or Miltenyi's Prodigy (both are often used for on-site manufacturing).

[panabee]

would you mind sharing what you think are the largest bottlenecks to (1) 24-hr turnaround and (2) CAR-T therapy for < $10K?

[puzzlingcaptcha]

I think that's near impossible to achieve with an autologous product. To meet those two goals I think you'd need to have an allogenic product manufactured and QCd in advance in a large batch, which you could thaw and infuse on demand. The problem with that approach is histocompatibility (HLA) matching, but several companies are working on that.

[panabee]

thanks for sharing. this is such an impactful space. hopefully someone one day can lower the cost to $10K or ideally $1K.