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by puzzlingcaptcha 960 days ago
The 'vein-to-vein' time (apheresis to infusion) is being shortened all the time, and you can already manufacture CAR-T cells in 24-48hrs, but it still takes about a week to clear quality assurance and release the product (microbiology, integrated copy number, integration site testing, autonomous growth potential etc). The reason being mostly that you don't want to accidentally replace patient's B cell cancer with a T cell cancer of your own making.
1 comments

Hah, you don’t have to tell me about validation and quality. Yes, they usually account for a significant time of anything in the pharma world.