What really kills me is acid reflux. If I get it at night I just have to wake up and sit down or stand up until it passes... fortunately it happens rarely enough and I kind of know what will trigger it, but it still sucks.
FWIW and for others reading this. If you experience reflux regularly, go get checked. I had an undiagnosed H Pilory infection for years (can lead to cancer). 2 weeks of antibiotics fixed it.
Alka-Seltzer always knocks reflux down for me pretty quick. Still get woken up by the reflux and have to haul myself out of bed to get the goods, but a few sips and I can get right back in bed.
I have some from Costco and IIUC you need to take it in the morning or something for 2 weeks? Never seemed to do much to me though, especially when I really need it.