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Prior evidence suggests that sedentary behaviour increases blood biomarkers of cardiometabolic dysfunction.

They studied a hunter-gatherer tribe in Tanzania and found that despite having similar patterns of sedentary behaviour, their blood biomarkers of cardiometabolic dysfunction were much lower than those in industrialized nations. The authors posit that one reason for this is that sedentary behaviour in this group of individuals does not involve furniture -- rather, it usually involves a "deep squat", and the authors show that in this position the muscles are much more engaged than when someone sits in a chair.

This is consistent with evidence that breaking up periods of sitting with movement is good for you.

Their open-access paper talks about some evolutionary context for this hypothesis [1].

[1] 10.1073/pnas.1911868117