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by PumpkinSpice
974 days ago
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Acetaminophen has a narrow therapeutic index and can cause severe and irreversible liver injury in doses around 10 g. A single tablet usually contains 500 mg, but because it's a component of so many other "combo" cold meds, including some syrups, it's easy for people to overdose while mixing OTC products to get over a flu. Aspirin has a lower standard dose (325 mg), higher LD50 (probably around 20-25 g), and is generally safer. It has fallen out of favor because it's known to cause an exceedingly rare but deadly syndrome in a tiny percentage of children, and because it can have gastroenterological side effects. Ibuprofen is probably the safest option? I'm sure it can be overdosed, but it almost never happens, whereas acetaminophen results in tons of hospitalizations every year. |
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Are you kidding? Ibuprofen like most NSAIDS is terrible on the GI tract and the kidneys. People with healthy kidneys are usually fine with short courses, but even people with relatively mild chronic kidney disease should avoid NSAIDs.
People in their 20s that overuse NSAIDs end up needing kidney transplants. it's not that uncommon. The most common cause of peptic ulcer disease of this demographic (affluent westerners) after H pylori is NSAID use.
> It has fallen out of favor because it's known to cause an exceedingly rare but deadly syndrome in a tiny percentage of children
This has really nothing to do why aspirin has less common use among adults. Aspirin has poor analgesic effects relative to the doses and the risks of GI complications.
> acetaminophen results in tons of hospitalizations every year.
The impact of NSAID related complications is far greater in terms of kidney transplants and upper endoscopy interventions, and related ICU stays.