The brain doesn't run software it's an organ inside the body.
If you mean can we simulate a brain inside a computer the answer is no we can't it's unlikely that we can without building something similar to the brain which is why this product is a thing.
The brain very much does run a type of software. Yes, it's an organ, but the analogy to hardware and software is apt. That's like saying a BIOS doesn't run software it's a chip on a motherboard.
If you mean can we simulate a brain inside a computer the answer is no we can't it's unlikely that we can without building something similar to the brain which is why this product is a thing.
The physicality is important here.