[crtxcr]

I've been using three profiles for some time now and it works great.

One is a profile that I exclusively run in a Linux network namespace, where all traffic is routed over a wireguard VPN. A shellscript sets up the namespace, connects to a randomly selected VPN server, sets up routing and launches the Firefox profile in that namespace. That shell script is launched through a custom key shortcut.

The "normal profile" does not have many anti-tracking measures and privacy extensions enabled. I use this one for online banking or other personal activities which I don't want to route over a VPN. It's also synced with my phone.

A third profile is restricted to certain websites. It's pretty much a default Firefox, except for ublock. ublock filters ensure that only selected websites can be browsed in this profile. This profile does not clear cookies on exit etc. I use mainly it for web apps that require login.