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by lamontcg 981 days ago
RaTG13 differs from SARS-CoV-2 by a lot more than just an FCS
1 comments

How far away would it be? Would it still take millions and millions of bats or is it now within the realm of possibility to infect humanized mice and get SARS-CoV-2 out the other end?
Yes, you're still a thousand mutations away from each other. The FCS is tiny. The mutations are spread all over the entire genome--although the main areas are in spike RBD (which suggests that RaTG13 may not be able to use ACE2 at all). The PRRAR FCS that SARS-CoV-2 uses is also a previously-unknown-to-humans FCS and not one a human scientist would have naively guessed would work.
Thanks.