[Not_John]

"It compared outcomes in a group assigned a target of 25% CR (i.e., a 25% reduction in energy intake below baseline levels) with outcomes in an ad libitum diet control group. "

and

"... CALERIE TM participant requirements included:

    Absence of significant health problems, including diabetes, cancer, heart  and liver disease, and AIDS 
    Absence of medication use except oral contraceptives 
    Age from 20 to 50 (inclusive) for men and ages 20-47 (inclusive) for women
    Body mass index (BMI) of 22-27.9 (lean to slightly overweight) 
    No recent substantial weight loss
    No history of eating disorders, behavioral, or psychiatric problems 
    Use by women of an acceptable form of contraception throughout the study"

Source - https://calerie.duke.edu/background