| N = 1, but I’ve been taking 1700mg of metformin (in two split doses of 850mg) for five years. I was able to get the prescription from my doctor by presenting evidence and the rationale and design for the TAME trial. He was comfortable with this due to the strong safety history of the drug. Insurance covers it (though it’s very cheap anyway) and I pay nothing out of pocket. I live in Canada and also have private insurance through work. I had some gastrointestinal issues initially, but they weren’t serious, and my body adapted fairly quickly as they want away. I tried taking metformin while doing an 18:6 intermittent fast and gastrointestinal symptoms returned, so I won’t be doing that again. There is some debate about the benefits and risks of metformin, but so far I haven’t experienced negative side effects of concern to me. I’ve had various tests over the past five years—blood, urine, body composition, etc. As for the TAME trial, while there have been positive developments, I’m now doubtful it will ever actually run. I have a prediction market on Manifold right now that shows a 25% chance it will be listed on clinicaltrials.gov by the end of the year. I’m not trying to promote the market (the main benefit to me is more market participants hopefully means better forecasting), but if anyone’s interested, it’s here: https://manifold.markets/SimonSmith/will-the-targeting-aging... |