As someone who's worked in the field of used books, I can say from personal experience that's not quite true. It's pretty common to have to type in an ISBN for a variety of reasons. Many times the barcodes have been covered up or defaced, and many publications don't have barcodes in the first place.
Since this is the second time I've mentioned Bowker, let me just say that I do not and have never worked for them or with them, although I did meet with their reps several times when I worked in a different part of digital publishing. It's just that they're inescapable when you're talking about ISBNs.