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by tcj_phx 996 days ago
My friend eventually figured out for herself that she has the genetic condition of not being able to methylate the provitamin folic acid into Vitamin B9 (important for dna synthesis). She told me how adding L-methylfolate to her routine was like flipping a switch from ‘depressed’ to ‘not-depressed’. #MTHFR: https://twitter.com/jamesknochel/status/1595562181692907520?...

MAOIs are reasonably effective at lifting people’s moods, and start to work right away - helpful for breaking 'depressions' negative feedback loop.

SSRIs were promoted because they were profitable, not because they’re especially effective. Now that the patents have expired the harms of these drugs are getting more attention.

1 comments

SSRI are way better tolerated than irreversible MAOIs.