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"We used 2 definitions for depression: (1) a strict definition requiring self-reported clinician–diagnosed depression and regular antidepressant use and (2) a broad definition requiring clinical diagnosis and/or antidepressant use. We estimated hazard ratios (HRs) and 95% CIs for depression according to quintiles of UPF intake using Cox proportional hazards models, with adjustment for known and suspected risk factors for depression, including age, total caloric intake, body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), physical activity, smoking status, menopausal hormone therapy, total energy intake, alcohol, comorbidities (eg, diabetes, hypertension, dyslipidemia), median family income, social network levels, marital status, sleep duration, and pain." https://jamanetwork.com/journals/jamanetworkopen/fullarticle... |