This Developers Life - http://www.thisdeveloperslife.com/
Mixergy - http://mixergy.com/homepage/?skip=yes
Startups for the Rest of Us - http://www.startupsfortherestofus.com/
This Week in Startups - http://www.thisweekinstartups.com/
Guardian Tech Weekly - http://www.guardian.co.uk/technology/series/techweekly
Infinite Monkey Cage - http://www.bbc.co.uk/podcasts/series/timc
60s Science - http://www.scientificamerican.com/podcast/podcasts.cfm?type=...
Skeptics Guide to the Universe - http://www.theskepticsguide.org/archive/podcast.aspx?mid=1