So the data is interesting and speaks for itself, but of course, let's ask the ancillary but potentially relevant questions: why sci rep? Why isn't this in a higher impact journal? Is sci rep even read in medicine?
Scientific reports is read in many places, including in medicine.
Regarding your 'low-impact' comment I have a few thoughts.
1. Although this is a large study, they do not find any world shocking new insights that are otherwise found in other studies. Cholesterol phenotypes are very well studied. Changing a guideline is usually not done based on a study of a single population.
2. They do not account for medication usage which confounds results.
3. They do not find a causal relationship between cholesterol and mortality, only provide an association.
Regarding your 'low-impact' comment I have a few thoughts. 1. Although this is a large study, they do not find any world shocking new insights that are otherwise found in other studies. Cholesterol phenotypes are very well studied. Changing a guideline is usually not done based on a study of a single population. 2. They do not account for medication usage which confounds results. 3. They do not find a causal relationship between cholesterol and mortality, only provide an association.