[contravariant]

Trying to mess with any part of the metabolism is going to have consequences.

You can even take a more direct route and make the body just burn more energy. Works perfectly well, technically doesn't have any side effects, though you have to take into account that burning energy results in heat.

And in all cases homeostasis is just going to attempt to return to normal as soon as possible. You need to somehow break the loop of your body wanting more energy to maintain its weight. This is a lot trickier because the checks and balances are everywhere and affect everything.

[loeg]

> You can even take a more direct route and make the body just burn more energy. Works perfectly well, technically doesn't have any side effects, though you have to take into account that burning energy results in heat.

Historically, https://en.wikipedia.org/wiki/2,4-Dinitrophenol .

[danielheath]

Very glad we have eg CSIRO comparing how well various methods overcome that homeostasis and publishing their results.

Successful weight loss has been totally life-changing for me, and being able to access reliable info on what works long term was a key part of it.

[jacquesm]

The real pay-off of weight loss is later in life when your joints and tendons will not be worn to bits.

[Scoundreller]

And less likely to break bones (butttttttt (pun intended?) less padding against impact). So maybe that part's a draw.