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"Compared with individuals who had not been exposed to sedentary behavior, individuals who were exposed to sedentary behavior had a 30% higher risk of experiencing dementia. Sedentary behavior was associated with several chronic diseases that were also associated with cognitive impairment and risk of dementia. Previous data suggested that prolonged sedentary time could impair glucose and lipid metabolism, which were recognized as the risk factors for cognitive decline and all-cause dementia. In addition, inflammation was also identified as a potential risk factor for dementia."

- From this meta-analysis: Association between sedentary behavior and the risk of dementia: a systematic review and meta-analysis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174309/)