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by DoctorOetker 1011 days ago
>Even if you were able to start sequencing immediately, standard sequencing alone takes on the order of a day. And then depending on your computational methods, could take another few hours.

Check the second response at https://www.biostars.org/p/9552596/

For a Minion most of the data is generated in the first half-hour or hour.

You can stop the sequencing process as soon as you have sufficient coverage (see the first response at the same link).

> Remember that it's not just the sequencer, you also need extraction, so you need to add a centrifuge, a vortex, a pipetting station, a PCR machine, a -20 C freezer, a spectrophotometer and a whole lot of reagents, additional personnel, and probably tons of other things I'm forgetting.

Apart from the freezer these devices aren't too sensitive to linear accelerations expected on a mothership of this size. Centrifuge and PCR exist in small and inexpensive form factors.

Non-linear accelerations (tilting of the ship): cut a square out of a table rigidly attached to the ship, mount ball bearings for one axis to a square, and mount ball bearings to the axis orthogonal to the first axis, then mount the equipment to a smaller square piece originally cut from the table. Place the equipment you wish to isolate from vertical rotations on this center piece of table, and add a weight to move the center of mass a few cm below the intersection of both axes of rotation. THat center piece of table will now stay horizontal regardlas of ship riding waves or not.

Additional personnel? One for the centrifuge, one for the PCR, one.. ? at some point one is bending over backwards to defend nonsense.

Regarding the freezer. It's not like freezers on ships don't exist. At a fundamental level its a non-problem since thermo-electric devices could be used, but I think its reasonable to assume even refrigerant-based freezers have special designs for ships.