[lgg]

This is awesome. macOS actually enables the same env var protections by default if your process is opted into the hardened runtime. You can do that by passing —-options=runtime to your codesign invocation.

[josephcsible]

What's the easiest way to use those variables anyway on a binary that's been compiled that way? Does it need SIP to be off?

[LoganDark]

You could try completely unsigning the binary: https://reverseengineering.stackexchange.com/a/13623

This won't work for everything, and it probably does need SIP to be off (also make a backup!) but it might be a way to get something to work.

[saagarjha]

Yes, and then patch dyld to enable library insertion again.