[rthz]

It's done currently in Pyodide: Python with DOM integration running with WASM. Minimal application with stdlib is around 5.5MB after compression now. Not small but still manageable depending on the use case.

Still I agree with your other comments, and in particular not being able to share caches in the browser is very unfortunate (but understandable).

[tyingq]

Yes, it works...but it puts python at a big disadvantage in terms of size and performance. The DOM integration, for example, works, but isn't what it could be if WASM had more direct support for it.