[vidarh]

To add to the MorphOS option, there's also AROS which aims for more Amiga compatibility, but also runs natively on x86 PCs or hosted under Linux (you get a window with the full AROS desktop) w/out a VM if you want.

(At one point I had a AROS setup that booted straight into FrexxEd with my Linux home directory made available, and Linux-hosted AROS "booted" the entire OS and started FrexxEd faster than my admittedly bloated Emacs setup would start....)

[actionfromafar]

To me the most interesting AROS is the 68000 port of AROS, which enables fully open source Amiga hardware clones and emulators.