[amts]

Though toxicity seems the main difference, comment above is talking about experience and not molecular mechanisms of action.

In a similar vein, if someone would ask a distinguished professor of neuroscience to provide a full description of the exact brain molecular state that "generates" an exact salvia experience (including any communicative content), s/he would fail.

[capableweb]

> Though toxicity seems the main difference, comment above is talking about experience and not molecular mechanisms of action.

As someone who has done both, in similar settings, I'd still disagree with this. Datura was devilish like none other and probably one of the few psychedelics I'd never do again.

[amts]

Datura being anticholinergic degrades the effect of acetylcholine, which is one of the components of (regular) attention. So no wonder it seems scary. But would you have the same experience after, for example, 10 days of continuous mindfulness/focusing meditation? Or after 30 days?