[hwillis]

> But you can only know that by having a large sample of very “stable” (have few genetic irregularities) gene samples compared to a large pool of samples from people with very narrow and pronounced gene irregularities, right?

No- A "gene" isn't an A/G/C/T- it's a sequence of 1000-1000000 base pairs. Each gene has a well-defined start/stop sequence called a start/stop codon. When people have genetic differences, one (an SNP- single nucleotide polymorph) of the tens of thousands of base pairs in that gene is different. Even for genes that are entirely "missing" in some people, they're really just different in a way that makes them nonfunctional.

Does that make it obvious how sequencing all those genes is useful, even if everyone has different genes? It tells us 99.999% of how proteins are coded, even if individual variation is the other .001%.