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by dekhn
1036 days ago
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The public Human Genome Project used a group of people but most of the sequence library was derived from a single individual in Buffalo, NY. The celera project also used a group of people but it was mostly Venter's genome https://www.nytimes.com/2002/04/27/us/scientist-reveals-secr... I believe more recent sequencing projects have used a wider pool of individuals. I think some projects pool all the individuals and sequence them together, while others sequence each individual separately. This isn't really so much of a problem since the large-scale structure is highly similar across all humans and we have developed sophisticated approaches to model the variations in individuals, see https://www.biomedcentral.com/collections/graphgenomes for an explanation of the "graph structure" used to reprsent alternatives in the reference, which can include individual single nucleobase differences, as well as more complex ones such as large deletions in one individual, to rearrangements and even inversions. |
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