[SkyMarshal]

I've never used iTerm, but does iTerm run from a daemon and remember your window config even when you close the window?

The main use case for that in tmux is when you ssh into a server, start tmux and vim, do some work, then log out without shutting down the tmux daemon. You can then log back in the next day, reattach to the tmux daemon, and continue with your tmux layout the way it was when you logged out the previous day.

[superchink]

No, but they maintain a fork of tmux that integrates into the iTerm UI to provide that type of functionality. It's a work in progress, but it's coming along nicely.

http://code.google.com/p/iterm2/wiki/TmuxIntegration