It's serious enough that it's led to suicides[1] and suicidal ideation[2][3][4].
Fortunately, a research lab called Foregen is near to a solution to reverse male genital mutilation[5].
[0] https://www.foregen.org/the-human-foreskin
[1] https://www.bbc.com/news/uk-england-47292307
[2] https://youtu.be/vVuEST8RdL8
[3] http://reddit.com/r/circumcisiongrief
[4] http://reddit.com/r/foreskin_restoration
[5] https://foregen.org