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by briHass
1036 days ago
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I'm interested in niacin, especially for it's effects on lowering LPa, which it seems to be one of the few ways to do so. However, I thought the common concern is that it promotes insulin resistance. Even though it seems to be a bit of a miracle drug for cholesterol numbers, on paper, it's effects on actual longevity are non-existent, proposed to be due to the IR. Have you read otherwise? |
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Chromium can offset insulin resistance, and whilst niacin can increase growth hormone and those ensuing reactions in the body, the demand for chromium will go up.
Chromium also increases Interleukin 1 and 2, which is like the the homing beacon for the immune response. Ferroptosis seems to me like using Fe based ROS to do the destruction, when not enough beta alanine and thus Super Oxide Dismutase to neutralise the feROS is present.
Not enough chromium, you'll see obesity, diabetes, impaired immune response.
Ironically smokers are probably after the "toxic" heavy metals like nickel which causes mitochondria dysregulation in much the same way mercury in amalgam dental fillings cause mitochondria dysregulation to reduce bacteria. Problem is smoking is bypassing the evolved normal digestive system measures to handle these heavy metals, like bile acids.
I think we dont get enough nickel in out diet considering it also seems to reduce the incidence of osteoarthritis, and a zinc-nickel combo is fantastic for bones. Zinc will give you a better cholesterol profile as well, and has been show to shrink receptors on some bacteria, which effectively starves them reducing the uptake of manganese, which could explain why zinc is considered antibacterial.
Problem with nickel inhalation from smoking or welding is it causes lung cancer as its a metallic allergen, and everything in moderation, which is harder to control via inhalation when compared to digestion.