[joshjhargreaves]

All I can say is that having significant gut dysbiosis is enough to have significant fatigue - think for sure, you can end up having fatigue from cell energy production issues, but it's clear to me that there are definitely different causes of CFS.

[vaelin]

It's possibly the same thing. Endoplasmic Reticulum Stress, the type of stress which may cause this protein to become elevated, was induced in mice by exposing them to endotoxin, a type of toxin produced in the gut.

So gut dysbiosis may trigger this very mechanism.