[cyberax]

> None has any demonstrated underlying pathology

Mechanical damage to parts of the brain can cause personality changes. Multiple neurological syndromes are directly linked to macroscopic brain changes. This includes schizophrenia, traumatic brain injuries dramatically increase its risk.

We also know that schizophrenia almost never happens along with epilepsy. They are almost mutually exclusive.

It's fair to say there is no single macroscopic trigger for schizophrenia, but that's it.