[seanp2k2]

Plenty. Protip from a sysadmin in the hosting industry: don't even try to run your own MTA unless you're just curious as to how hard reliable mail delivery is.

Use GMail or similar. Use iContact / StreamSend / MailChimp for newsletters. Use Google Apps for any business you start.

[icebraining]

Well, the (sending) MTA is not exactly mine: I configured exim to send everything through my ISP's. Of course, the domain is still managed by me, and so is reception, although I keep Google Apps (free) for the backup MX.