[wheels]

Some random anecdata:

I have a chronic sleep disorder, "Non-24 Sleep / Wake Disorder", which means my sleep floats pretty freely and doesn't naturally sync up with the sun. For the most part, I've structured my life for that to be ok, but sometimes it's not. I basically use melanin to bludgeon myself into a more normal sleep pattern when I have to. I usually start with 2 mg, 30-60 minutes before I want to sleep, but often when that doesn't work, take another 3 mg, which usually gets the job done. Often I don't even notice 1-2 mg, but 5 mg does register reasonably strongly.