>"Moreover, the identification of a distinct isoform of PCNA associated with cancer cells has potentially opened a novel avenue for the development of new chemotherapeutics"
A distinct isoform does not necessarily mean a mutation.
The coding sequence for an isoform is part of the normal gene DNA sequence, but the cells can “choose” which version to make. In this case the caPCNA isoform is the form predominantly expressed in cancer cells.
(There is a mechanism where novel splicing isoforms can be produced by a mutation, but this doesn’t seem to be one of those.)
The coding sequence for an isoform is part of the normal gene DNA sequence, but the cells can “choose” which version to make. In this case the caPCNA isoform is the form predominantly expressed in cancer cells.
(There is a mechanism where novel splicing isoforms can be produced by a mutation, but this doesn’t seem to be one of those.)