[kylehotchkiss]

I am a total layperson in medicine but I try to challenge myself to read Derek Lowes blog posts and comments here from people like isoprophlex who do understand it. I really appreciate the simplicity of this solution - it doesn't need to be customized for each person, it doesn't need years of work on targeting, it's stable, potentially with few side affects of users. I know even this is a long shot but if it works, the power to change society! I imagine that it would even encourage cancer screening earlier for people to make for more effective treatments.

A working treatment for many cancers will bump many more preventable forms of deaths up the charts - obesity, cars, weapons. I hope that people will be inspired to take more significant actions to reduce those when we've tackled these really really hard ones.

And due to the potential low-cost, easy administration, and storage requirements, I am reminded a bit of how antibiotics ended up working in developing countries. Doctors prescribe them for every pain, making them ineffective at best and spawning antibiotic-resistant bugs at worst. I hope the researchers are able to consider this angle (overprescription) before these medicines become a widely distributed thing in other parts of the world.

It's an exciting decade for medicine. I hope that if we don't see the efficacy we want with this one, that more "simple" formulations will come around that do work.

[fluidcruft]

Infectious diseases are different because they jump from host/reservoir to host/reservoir and can take their "experience" with them. Cancers spawn off from normal cells that mutate randomly. So the general scheme is that cancers (and each person's cancer's drug-resistance) develops from scratch in isolation within each person. Basically there's no real mechanism for one person's cancer to translate/share its experience against drugs with another person's cancer. Some cancers are related to viruses by increasing mutation rates which in turn increases the chance of a cancer developing. So basically I wouldn't expect overprescription to produce drug-resistance the way it can for anti-virals and anti-bacterials.