[Veserv]

The Mesoamerican civilizations did not have copper, bronze, or iron metallurgy which is a prerequisite for making the metal rims needed for transportation wheels. A wooden wheel without a metal rim is too fragile for transportation.

Without the wheel, humans are actually relatively comparable to other pack animals in carrying efficiency. It is the wheel that makes moving larger loads more efficient which makes it advantageous to domesticate pack animals that can exert greater force.

[AlotOfReading]

Bronze was extremely common in Mesoamerica for household goods like needles and fishhooks. Copper was also common, but mainly for ceremonial and ornamental objects like bells.

As for wooden wheels being too fragile, you can build a perfectly good wheel without metal bands. It's simply going to be heavy and annoying if you're trying to run a wagon to Oregon.