[nazgulnarsil]

just a heads up that microdosing dmt (non psychoactive doses, just a mg or two) are game changing instant cures for some forms of cluster headaches. Can be worth moving to a locale where plant based medicine has at least been decriminalized.

[Mumps]

Do you have any studies you can point me toward on this?

A quick pubmed search of `("cluster headache" OR "migraine") AND ("dmt" or "dimethyltryptamine"), 14 results, has nothing relevant.

Not all truth is published -- but I frequently see poor claims of using psilocybin ("magic mushrooms") to treat migraine/cluster headache, of which, the clinical effects are potentially dubious [0], [1], [2], [3], [4], [5] in particular which I believe to be an effect driven by the desperation for treatment [6], [7] when nothing else has worked.

[0] https://pubmed.ncbi.nlm.nih.gov/22129843/ [1] https://pubmed.ncbi.nlm.nih.gov/33184743/ [2] https://pubmed.ncbi.nlm.nih.gov/35718005/ [3] https://pubmed.ncbi.nlm.nih.gov/16801660/ [4] https://pubmed.ncbi.nlm.nih.gov/36597700/ [5] https://pubmed.ncbi.nlm.nih.gov/36416492/ [6] https://pubmed.ncbi.nlm.nih.gov/28870224/ [7] https://pubmed.ncbi.nlm.nih.gov/30290701/

I get really worried about people suggesting psychoactive drugs with no clinical proof for it :(

[xyzwave]

Not sure about DMT, but LSD seems to show promise.

https://www.science.org/content/article/lsd-alleviates-suici...

[nazgulnarsil]

Not really, it's mostly gathered from cluster headache forums online.

[consumer451]

I have tried everything including off-label surgery, that's one I have not. Thanks.

[pluijzer]

Just as another data point, my ex-girlfriend also had debilitating cluster headaches. Psilocybin, not microdosing just tripping on it, would make it stop for a couple of months.

Also, you might be familiar that taking pure oxygen during an attack in known to stop the attack. The problem is that it builds a tolerance were you need more and more which brings problems of its own.

[di456]

I know someone who's had success stopping an in-progress visual migraine with low dose psilocybin.

They tried it based on some published research. Here's one such study. https://n.neurology.org/content/66/12/1920

[keepamovin]

By off-label surgery are you referring to trepanning? https://en.wikipedia.org/wiki/Trepanning

Also, on a possibly constructive note, have you investigated mycotoxins or heavy-metals (as a possible cause)?

[consumer451]

> By off-label surgery are you referring to trepanning? https://en.wikipedia.org/wiki/Trepanning

Wow! Jeez, I mean the thought of doing that myself has certainly crossed my mind in semi-jest, mid attack, but nope.

I found this old study [0] and based on that I had endoscopic sinus surgery. It stopped a 9 month cluster and I did not have another attack for almost a year. The surgeon did it because my sinuses were opaque, but the reason I did it was with the hope of the chance of cluster benefit.

[0] https://pubmed.ncbi.nlm.nih.gov/8924166/

[keepamovin]

Poor you! It must be so painful :(

Are there any foods or drinks that bring it on or make it worse or better? Sorry if it's a dumb question, I'm just curious!

[consumer451]

Thanks. Alcohol or an empty stomach brings them on, or sometimes they just happen.

There is an instant solution to stop the pain, it’s in that study as a footnote I believe. But it’s illegal, extremely habit forming, and very expensive.

I have heard that there is a new novocaine nasal spray coming out. That should do the trick if I can ever get my hands on it.