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by cactusplant7374 1056 days ago
The intervention is Metformin during Covid onset?
2 comments

I had the same question. Apparently people who had already been taking Metformin for diabetes were at lower risk of severe Covid [1], which explains why Metformin is being studied.

Looks like the same authors found that Metformin as a treatment after Covid diagnosis did not significantly reduce the the risk of hospitalization or death, even though it does reduce incidence of long Covid.

[1] https://www.covid19treatmentguidelines.nih.gov/therapies/mis...

[2] https://www.nejm.org/doi/full/10.1056/NEJMoa2201662

Yep - the long Covid endpoint was a secondary one that was added to the trial once people realized that might be an issue. The original trial was to see whether administering metformin / fluvoxamine / ivermectin would have any impact on disease severity.

https://clinicaltrials.gov/study/NCT04510194?term=NCT0451019...

Spoiler: "None of the three medications that were evaluated prevented the occurrence of hypoxemia, an emergency department visit, hospitalization, or death associated with Covid-19." [https://pubmed.ncbi.nlm.nih.gov/36070710/]

But they already had this population enrolled when Long Covid started becoming an issue, so they extended the study to see what impact the same 3 drugs would have on incidence of long covid.

For people who are overweight, it looks like. It makes one wonder if it would only work for them, or if long COVID affects them more.