[tincholio]

The layers do take a bit of time to get used to, but they become transparent, after a while. As for punctuation locations, I've exploited that to my advantage, I have brackets and braces (which I use a lot of, for Clojure) just next to my left ring and middle finger, and parenthesis are also trivially reachable, of course. (all this on a Dactyl Manuform, with 46 keys total)

[zihotki]

It's great that layers work fine for you. But they may not work for other person. Other person may not want to invest his time into learning layers. Or he also has to use a normal keyboard with standard shortcuts. Or there may be any other reason.

Market is definitely missing a full split keyboard (87+ keys). I'm also looking for one and I hate using keyboards with reduced number of keys.

[Symbiote]

This isn't totally up to date, but it might help: https://aposymbiont.github.io/split-keyboards/

(My site.)